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The production method of nicotinamide in China
(1) β - Methylpyridine is oxidized by air to form nicotinic acid, which reacts with ammonium hydroxide and is then dehydrated by heating.
(2) Put niacin, boric acid, and ammonia water into the reaction pot, stir and introduce ammonia gas, then heat up and dissolve; Then distill and recover ammonia, and transfer it to a dehydration pot for further concentration after reaching 120 ℃; When the temperature reaches 145 ℃, start adding liquid ammonia and continue the ammonia reaction at 185-190 ℃ for 20-30 hours. Then cool down to 130 ℃, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70-80 ℃ for 2 hours; After the reaction, the filtrate was filtered while hot, and the filtrate was cooled and precipitated in water for 24 hours. The crystals were separated, washed with ethanol, and dried to obtain the finished product with a yield of 89%.
(3) Put niacin, boric acid, and ammonia solution into the reaction pot, stir and introduce ammonia gas to dissolve. Then, distill and recover the ammonia until it reaches 120 ℃, and transfer it to a dehydration pot for further concentration. When the temperature reaches 145 ℃, start adding liquid ammonia and continue the ammonia reaction at 185-190 ℃ for 20-30 hours. Then cool down to 130 ℃, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70-80 ℃ for 2 hours. After the reaction, filter while hot, and the filtrate is cooled in water for 24 hours to separate crystals. Wash and dry with ethanol to obtain the finished product with a yield of 89%.
(4) Obtained by salt formation of niacin and ammonia water, followed by dehydration.
Production methods and export output of nicotinamide in China
In 2024, China's production of nicotinamide will be approximately 28000 tons. In addition, the market demand for nicotinamide in China is 13000 tons, while the export volume remains at a high level, reaching 14000 tons
